44. Tarasova E., Dhindwal S., Popp M., Hussain S., Khayat R*. Mechanism of DNA Interaction and Translocation by the Replicase of a Circular Rep-Encoding Single-Stranded DNA Virus. mBio. 2021 Aug 31;12(4):e0076321. doi: 10.1128/mBio.00763-21. Epub 2021 Jul 27.

43. Khayat R*., Russell R.S. It is all about the Structure. Viral Immunol. 2021 Jan-Feb;34(1):1-2. doi: 10.1089/vim.2020.0341.

42. Murphy E.L., Singh K.V., Avila B., Kleffmann T., Gregory S.T., Murray B.E., Krause K.L., Khayat R*., Jogl G. Cryo-electron microscopy structure of the 70S ribosome from Enterococcus faecalis. Sci Rep. 2020 Oct 1;10(1):16301. doi: 10.1038/s41598-020-73199-6


41. Khayat R*., Wen K., Alimova, A., Gavrilov B., Katz A., Galarza M. J., Gottlieb P., Structural characterization of the PCV2d genotype at 3.3 Å resolution reveals differences to PCV2a and PCV2b genotypes, a tetranucleotide, and an N-terminus near the icosahedral 3-fold axes. Virology. 10.1016/j.virol.2019.09.00

40. Dhindwal S., Feng S., Khayat R*., The Arginines in the N-terminus of the Porcine circovirus 2 virus like particles are responsible for disrupting the membranes at neutral and acidic pH. JMB 10.1016/j.jmb.2019.05.044

39. Dhindwal S., Avila B., Feng S., Khayat R*., Porcine Circovirus 2 uses a multitude of weak binding sites to interact with heparan sulfate and the interactions do not follow the symmetry of the capsid. J. Virol 2019 93, 10.1128/JVI.02222-18


38. Alphonse S., Itin B., Khayat R., and Ghose R., Sequential Protein Expression and Capsid Assembly In Cell Towards the Study of Multi-Protein Viral Capsids Using Solid-State NMR Techniques Biochemistry 2018 57, 1568-1571.


37. Tarasova E., Farafonov V., Khayat R., Okimoto, N., Komatsu T., Taiji M., and Nerukh D., All atom molecular dynamics simulations of entire virus capsid reveal the role of ion distribution in capsid stability J. Phys. Chem. Letters 2017 8, 779-784. PMC5391438


36. Wang N, Zhan Y, Wang A, Zhang L, Khayat R, Yang Y. In silico Analysis of Surface Structure Variation of PCV2 Capsid Resulted from Loops Mutation of Its Capsid Protein (Cap). J. Gen. Virol. 2016 97, 3331-3344.


35. Murin CD, Julien JP, Sok D, Stanfield RL, Khayat R, Cupo A, Moore JP, Burton DR, Wilson IA, Ward AB. Structure of 2G12 Fab2 in Complex with Soluble and Fully Glycosylated HIV-1 Env by Negative-Stain Single Particle Electron Microscopy. J. Virology 2014 Sep 1;88(17):10177-88.

34. Veesler D, Khayat R, Krishnamurthy S, Snijder J, Huang RK, Heck AJ, Anand GS, Johnson JE. Architecture of a dsDNA Viral Capsid in Complex with Its Maturation Protease. Structure. 2014 Feb 4;22(2):230-7.


33. Klasse PJ, Depetris RS, Pejchal R, Julien JP, Khayat R, Lee JH, Marozsan AJ, Cupo A, Cocco N, Korzun J, Yasmeen A, Ward AB, Wilson IA, Sanders RW, Moore JP. Influences on trimerization and aggregation of soluble, cleaved HIV-1 SOSIP envelope glycoprotein. J. Virology 2013 Jul 3.

32. Khayat R, Lee JH, Julien JP, Cupo A, Klasse PJ, Sanders RW, Moore JP, Wilson IA, Ward AB. Structural characterization of cleaved, soluble human immunodeficiency virus type-1 envelope glycoprotein trimers. J. Virology 2013 Jul 3.

31. Kong L, Lee JH, Doores KJ, Murin CD, Julien JP, McBride R, Liu Y, Marozsan A, Cupo A, Klasse PJ, Hoffenberg S, Caulfield M, King CR, Hua Y, Le KM, Khayat R, Deller MC, Clayton T, Tien H, Feizi T, Sanders RW, Paulson JC, Moore JP, Stanfield RL, Burton DR, Ward AB, Wilson IA. Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120. Nat. Struct. Mol. Biol. 2013 Jul;20(7):796-803.

30. Julien JP, Sok D, Khayat R, Lee JH, Doores KJ, Walker LM, Ramos A, Diwanji DC, Pejchal R, Cupo A, Katpally U, Depetris RS, Stanfield RL, McBride R, Marozsan AJ, Paulson JC, Sanders RW, Moore JP, Burton DR, Poignard P, Ward AB, Wilson IA. Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans. PLoS Pathogens 2013 May;9(5):e1003342.


29. Ekiert DC, Kashyap AK, Steel J, Rubrum A, Bhabha G, Khayat R, Lee JH, Dillon MA, O'Neil RE, Faynboym AM, Horowitz M, Horowitz L, Ward AB, Palese P, Webby R, Lerner RA, Bhatt RR, Wilson IA. Cross-neutralization of influenza A viruses mediated by a single antibody loop. Nature. 2012 Sep 27;489(7417):526-32.

28. Schneemann A, Speir JA, Tan GS, Khayat R, Ekiert DC, Matsuoka Y, Wilson IA. A virus-like particle that elicits cross-reactive antibodies to the conserved stem of influenza virus hemagglutinin. J Virology. 2012 Nov;86(21):11686-97.

27. Dreyfus C, Laursen NS, Kwaks T, Zuijdgeest D, Khayat R, Ekiert DC, Lee JH, Metlagel Z, Bujny MV, Jongeneelen M, van der Vlugt R, Lamrani M, Korse HJ, Geelen E, Sahin Ö, Sieuwerts M, Brakenhoff JP, Vogels R, Li OT, Poon LL, Peiris M, Koudstaal W, Ward AB, Wilson IA, Goudsmit J, Friesen RH. Highly conserved protective epitopes on influenza B viruses. Science. 2012 Sep 14;337(6100):1343-8.

26. Depetris RS, Julien JP, Khayat R, Lee JH, Pejchal R, Katpally U, Cocco N, Kachare M, Massi E, David KB, Cupo A, Marozsan AJ, Olson WC, Ward AB, Wilson IA, Sanders RW, Moore JP. Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers. J Biol Chem. 2012 Jul 13;287(29):24239-54.


25. McLellan JS, Pancera M, Carrico C, Gorman J, Julien J-P, Khayat R, et al., Wilson IA, Kwang P. Structure of Variable Regions 1 and 2 of HIV-1 gp120 in Complex with Broadly Neutralizing Antibody PG9. Nature 2011 Nov. 23;480(7377):336-43.

24. Pejchal R*, Doore KJ*, Walker LM*, Khayat R*, Huang PS*, Wang SK, et al., Wilson IA. A potent and Broad Neutralizing Antibody Recognizes and penetrates the HIV Glycan Shield. Science 2011 Nov. 25:334(6059):1097-103. * Contributing first author.

23. Khayat R, Johnson JE. Pass the Jelly Rolls. Structure 2011 Jul 13; 19(7):904-6.

22. Khayat R*, Brunn N, Speir JA, Hardham JM, Ankenbauer RG, Schneeman A, Johnson JE. The 2.3-angstrom structure of porcine circovirus 2. J. Virology. 2011 Aug;85(15):7856-62. *Corresponding author.

21. Wang K, Fu CY, Khayat R, Doerschuk PC, Johnson JE. In Vivo Virus Structures: Simultaneous classification, resolution enhancement, and noise reduction in whole-cell electron tomography. J. Struct. Biol. 2011 Jun;174(3):425-33.

20. Huang RK, Khayat R, Lee KK, Gertsman I, Duda RL, Hendrix RW, and Johnson JE. The Prohead-I structure of Bacteriophage HK97: Implications for Scaffold-mediated Control of Particle Assembly and Maturation. J. Mol. Biol. 2011 May 6; 408(3):541-54

19. Khayat R, Johnson JE. Evolution of Viral Capsid Structures – the Three Domains of Life. Structural Virology. Eds. Mavis Agbandje-McKenna and Robert McKenna. Royal Society of Chemistry 2011, 165-181.

18. Fu C, Wang K, Gan L, Lanman J, Khayat R, Young MJ, Jensen GJ, Doerschuk PC, and Johnson JE. In vivo assembly of an archaeal virus studied with whole cell electron cryotomography. Structure 2010; 10(12);1579-1586.

17. Matsui T, Lander G, Khayat R, Johnson JE. Subunits fold at position-dependent rates during maturation of a eukaryotic RNA virus. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):15111-5.

16. Khayat R, Fu C, Ortmann AC, Young MJ, Johnson JE. The architecture and chemical stability of the archaeal Sulfolobus turreted icosahedral virus. J. Virology 2010; Sep; 84(18); 9575-83.

15. Khayat R*, Lander GC, Johnson JE. An automated procedure for detecting protein folds from sub-nanometer resolution electron density. J. Struct. Biol. 2010 Jun; 170(3);513-21. *Corresponding author.

14. Parent KN, Khayat R, Tu LH, Suhanovsky MM, Cortines JR, Teschke CM, Johnson JE, Baker TS. P22 coat protein structures reveal a novel mechanism for capsid maturation: stability without auxiliary proteins or chemical crosslinks. Structure 2010 Mar 10;18(3):390-401.

13. Lander GC, Khayat R, Li R, Prevelige PE, Potter CS, Carragher B, Johnson JE. The P22 tail machine at subnanometer resolution reveals the architecture of an infection conduit. Structure 2009 Jun 10;17(6): 789-99.

12. Banerjee M, Khayat R, Walukiewicz HE, Odegard AL, Schneemann A, Johnson JE. Dissecting the functional domains of a nonenveloped virus membrane penetration peptide. J. Virology 2009 Jul;83(13):6929-33.

11. Lawrence CM, Menon S, Eilers BJ, Bothner B, Khayat R, Douglas T, Young MJ. Structural and functional studies of archaeal viruses. J. Biol. Chem. 2009 May 8;284(19):12599-603.

10. Maaty WS, Ortmann AC, Dlaki M, Schulstad K, Hilmer JK, Liepold L, Weidenheft B, Khayat R, Douglas T, Young MJ, Bothner B. Characterization of the archaeal thermophile Sulfolobus turreted icosahedral virus validates an evolutionary link among double-stranded DNA viruses from all domains of life. J. Virology. 2006 Aug;80(15):7625-35.

9. Annedi SC, Biabani F, Poduch E, Mannargudi BM, Majumder K, Wei L, Khayat R, Tong L, Kotra LP. Engineering d-amino acid containing novel protease inhibitors using catalytic site architecture. Bioorg Med. Chem. 2006 Jan 1;14(1):214-36.


8. Khayat R, Tang L, Larson ET, Lawrence CM, Young M, Johnson JE. Structure of an archaeal virus capsid protein reveals a common ancestry to eukaryotic and bacterial viruses. Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18944-9.


7. Khayat R, Batra R, Bebernitz GA, Olson MW, and Tong L. Characterization of the Monomer-Dimer Equilibrium of Human Cytomegalovirus Protease. Biochemistry 2004 Dec. 20 43(2); 316-322.


6. Tao X, Khayat R, Christendat D, Savchenko A, Xu X, Goldshmith S, Honig B, Edwards A, Arrowsmith C, Tong L. Crystal structures of MTH1187 and its yeast ortholog YBL001c. Proteins 2003 52 478-80.

5. Khayat R, Batra R, Qian C, Halmos T, Bailey M, Tong L. Structural and Biochemical Studies of Inhibitor Binding to Human Cytomegalovirus Protease. Biochemistry 2003 42(4):885-891.


4. Batra R, Khayat R, Tong L. Molecular mechanism for dimerization to regulate the catalytic activity of human cytomegalovirus protease. Nat. Struct. Biol. 2001 Sep 8(9):810-7.

3. Batra R, Khayat R, Tong L. Structural studies of herpesvirus proteases. Protein and Peptide Lett. 2001 8, 333-342.

2. Khayat R, Batra R, Massariol MJ, Lagace L, Tong L. Investigating the role of histidine 157 in the catalytic activity of human cytomegalovirus protease. Biochemistry. 2001 May 29;40(21):6344-51.


1. Gao-Sheridan HS, Kemper MA, Khayat R, Tilley GJ, Armstrong FA, Sridhar V, Prasad GS, Stout CD, Burgess BK. A T14C Variant of Azotobacter vinelandii Ferredoxin I Undergoes Facile [3Fe-4S]0 to [4Fe-4S]2+ Conversion in Vitro but Not in Vivo J. Biol. Chem. 1998 273: 33692-33701.

Journal Covers



Available to the lab

The facilities below are fully accessible to members of the laboratory

and will be heavily used throughout the research

New York Structural Biology Center

Read More

Advanced Science Research Center

Read More

CUNY High Performance Comp. Center

Read More

Institute for Macromolecular Assemblies

Read More